Endocrine Abstracts

Primary aldosteronism (PHA) is one of the most common cause of secondary hypertension. It can possibly concern over 10% of hypertensive patients, but often is being under-recognised. The basic tool of case PHA detection is aldosterone to renin ratio (ARR). Appropriate cutoff value of ARR is still under discussion.We review occurrence of CT/MRI detectable adrenal gland laesions according to assigned ARR cutoff value. Retrospective data from 833 consecutiv...

Introduction: Primary hyperaldosteronism (PHA) is the most common hormonal cause of hypertension concerning about 5–12% of hypertensive individuals. Aldosterone to renin ratio (ARR) and 24 h urine aldosterone concentration (24-UAC) are important tools in PHA screening diagnostics. The most appropriate cutt off values predicting PHA are still being discussed. The study is to assess siutability and to determine optimal cut off values of ARR and 24-UAC for accurate PHA pred...

Laparoscopic surgery of adrenal tumours is widely used because of its high effectiveness, patients safety and relatively low cost. Current indications to adrenalectomy of oncological and endocrinological origin are highly accepted. However there is still lack of perfect clinical tool identifying malignant lesions. In everyday practice clinicians rely on low specific features, especially considering larger nonsecretory lesions to surgery.To show the lands...

Introduction: Primary hyperaldosteronism (PHA) is the most common hormonal cause of secondary hypertensionconnected with substantially higher cardiovascular morbidity and mortality than essential hypertension (EH). The association between aldosterone excess in PHA and mutations in KCNJ5 and CACNA1D genes has been previously described and the possible relation with gene polymorphisms was to consider. The present study is to assess possible association between polymorphisms of i...